Мы используем Cookies Этот веб-сайт использует cookie-файлы, чтобы предлагать вам наиболее актуальную информацию. Просматривая этот веб-сайт, Вы принимаете cookie-файлы.
The mechanism of cholesterylester accumulation in smooth muscle cells was investigated.
2
When membrane cholesterol levels are low, absorption of cholesterol effectively drives cholesterylester hydrolysis.
3
This difference is consistent with reports of the nonendocytotic selective uptake of HDL-associated cholesterylester.
4
Unexpectedly, cholesterylester transfer protein was not required to determine the human-like cholesterol lipoprotein profile.
5
Our results demonstrate that lysosomal hydrolysis of cholesterylester is independent of the presence of extracellular acceptors.
1
However, implication of LXRs in the selective uptake of cholesterylesters from lipoproteins in human macrophages has never been reported.
2
A simple method has been developed for labelling human plasma lipoproteins to high specific radioactivity with radioactive cholesterylesters in vitro.
3
They serve to transport endogenously synthesized lipids, mainly triglycerides (but also some cholesterol and cholesterylesters) to peripheral tissues.
4
Lysosomal acid lipase (LAL) is a key enzyme that cleaves cholesterylesters and triglycerides to generate free fatty acids and cholesterol in lysosomes.
5
Inhibition of ACAT, the enzyme which catalyses the intracellular formation of cholesterylesters, is a very attractive target for the treatment of hypercholesterolaemia and atherosclerosis.
1
The process begins with a vascular injury that is complicated by the deposition of cholesterolesters and cholesterol.
2
Increases in absolute amounts of EPA and DHA in fasting serum triglycerides, cholesterolesters and phospholipids were examined.
3
On the other hand, an EPA-rich diet produced a marked increase of this fatty acid, especially in cholesterolesters.
4
In contrast, the incorporation of exogenous oleate into secreted triacylglycerols and cholesterolesters was unaffected by deficiency of ABHD5.
5
The cholesterol ester transfer protein (CETP) facilitates the transfer of HDL cholesterolesters from plasma to the liver.
Использование термина cholesterol ester на английском
1
This occurs through the maintenance of caveolae cholesterol content by cholesterolester uptake from HDL.
2
Cholesteryl ester transfer protein is a plasma glycoprotein that transfers cholesterolester between lipoprotein particles.
3
Conclusions: The authors concluded that FEL irradiation can remove cholesterolester selectively from human atheromatous CA plaques.
4
In the absence of active LPL in the same tissue, inactive LPL only mediates selective cholesterolester uptake.
5
We observed abnormal hepatic accumulation of cholesterol in the homozygote individuals, supporting the diagnosis of cholesterolester storage disease.
6
The cholesterolester transfer protein (CETP) facilitates the transfer of HDL cholesterol esters from plasma to the liver.
7
Due to its higher sensitivity, mass spectrometry detected increased levels of cholesterolester relative to cholesterol in lipid extracts of gliomas.
8
Methods: The degradation of cholesterolester was estimated from changes in the infrared absorption spectra acquired using microscopic transmission Fourier transform infrared spectroscopy.
9
Peak signals derived from an ester bond of cholesterolester decreased in height as irradiation time increased and disappeared completely after 180 seconds.
10
Mice lacking Aster-B are deficient in adrenal cholesterolester storage and steroidogenesis because of an inability to transport cholesterol from SR-BI to the ER.
11
Importantly, we include GWAS results for all surveyed metabolites and demonstrate how this information highlights a role for AGXT2 in cholesterolester and triacylglycerol metabolism.
12
Because homozygosity for mutations in LIPA is known to cause cholesterolester storage disease, we performed directed follow-up phenotyping by noninvasively measuring hepatic cholesterol content.
13
In adult mice, it reduced triglycerides by 40% and increased lipoprotein particle uptake into muscle by 60% and cholesterolester uptake by 110%.
14
The process begins with a vascular injury that is complicated by the deposition of cholesterolesters and cholesterol.
15
Increases in absolute amounts of EPA and DHA in fasting serum triglycerides, cholesterolesters and phospholipids were examined.
16
On the other hand, an EPA-rich diet produced a marked increase of this fatty acid, especially in cholesterolesters.